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Genetic Engineering of Hematopoiesis for Targeted IFN- Delivery Inhibits Breast Cancer Progression

✍ Scribed by Escobar, G.; Moi, D.; Ranghetti, A.; Ozkal-Baydin, P.; Squadrito, M. L.; Kajaste-Rudnitski, A.; Bondanza, A.; Gentner, B.; De Palma, M.; Mazzieri, R.; Naldini, L.

Book ID
121438512
Publisher
American Association for the Advancement of Science
Year
2014
Tongue
English
Weight
914 KB
Volume
6
Category
Article
ISSN
1946-6234

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Genetic Engineering of Hematopoiesis for
Genetic Engineering of Hematopoiesis for Targeted IFN- Delivery Inhibits Breast Cancer Progression
✍ Escobar, G.; Moi, D.; Ranghetti, A.; Ozkal-Baydin, P.; Squadrito, M. L.; Kajaste πŸ“‚ Article πŸ“… 2014 πŸ› American Association for the Advancement of Scienc 🌐 English βš– 914 KB

The immunosuppressive tumor microenvironment represents a major hurdle to cancer therapy. We developed a gene transfer strategy into hematopoietic stem cells (HSCs) to target transgene expression to tumor-infiltrating monocytes/macrophages. Using a combination of transcriptional and microRNA-mediate