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Genetic engineering of Escherichia coli inorganic pyrophosphatase : Tyr55 and Tyr141 are important for the structural integrity

โœ Scribed by Reijo LAHTI; Tiina SALMINEN; Sari LATONEN; Pirkko HEIKINHEIMO; Katariina POHJANOKSA; Jukka HEINONEN

Book ID
115128589
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
525 KB
Volume
198
Category
Article
ISSN
1432-1327

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Deoxyuridine triphosphate nucleotidohydrolase (dUTPase), a ubiquitous enzyme of DNA metabolism, has been implicated as a novel target of anticancer and antiviral drug design. This task is most efficiently accomplished by X-ray crystallography of the relevant protein-inhibitor complexes. However, the