Hereditary nonpolyposis colorectal carcinoma (HNPCC) is the most common hereditary form of colorectal carcinoma (CRC) and may account for 5-10% of the total CRC burden. The discovery of DNA mismatch repair (MMR) genes, inclusive of hMSH2, hMLH1, hPMS2, and hMSH6, has enabled the identification of wh
โฆ LIBER โฆ
Genetic diagnosis of lynch syndrome II in an extended colorectal cancer-prone family
โ Scribed by Henry T. Lynch; Earlene K. Bronson; Patricia C. Strayhorn; Thomas C. Smyrk; Jane F. Lynch; Edward J. Ploetner
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 551 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Clinical impact of molecular genetic dia
โ
Henry T. Lynch; Patrice Watson; Trudy G. Shaw; Jane F. Lynch; Anne E. Harty; Bar
๐
Article
๐
1999
๐
John Wiley and Sons
๐
English
โ 114 KB
๐ 3 views
Molecular genetic evidence of the occurr
โ
John I. Risinger; J. Carl Barrett; Patrice Watson; Henry T. Lynch; Jeff Boyd
๐
Article
๐
1996
๐
John Wiley and Sons
๐
English
โ 757 KB
## BACKGROUND. The hereditary nonpolyposis colorectal carcinoma (HNPCC) syndrome is an autosomal dominant genetic disorder caused by the inheritance of a mutation in one of a family of genes encoding DNA mismatch repair (MMR) proteins. HNPCC manifests as genetic instability in linked tumors. Clini