Genetic determination of NOR activity in human lymphocytes from twins

✍ Scribed by A. F. Zakharov; A. Z. Davudov; V. A. Benjush; N. A. Egolina

• Publisher: Springer
• Year: 1982
• Tongue: English
• Weight: 577 KB
• Volume: 60
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00281258

✦ Synopsis

Activity of nucleolar organizer regions (NORs) was studied in cultured blood lymphocytes from 20 monozygotic (MZ) and 20 dizygotic (DZ) twin pairs. The number of Ag-stained NORs, the degree of staining, and the frequency of acrocentric associations were used as criteria of the NOR activity, the acrocentric chromosomes being identified by G-banding. Analysis of intrapair concordance as well as of intrapair variance showed the number of Ag + NORs and the size of Ag-deposits to be highly heritable traits. Intrapair differences in acorocentric association frequency were not significantly higher in DZ compared with MZ twins.