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Genetic determinants of glutamine synthetase in Drosophila melanogaster: role of the 10B8-11 region

โœ Scribed by Caggese, Corrado ;Caizzi, Ruggiero ;Grieco, Francesco ;Bozzetti, Maria Pia ;Ritossa, Ferruccio


Publisher
Springer
Year
1986
Tongue
English
Weight
662 KB
Volume
204
Category
Article
ISSN
0026-8925

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โœฆ Synopsis


In Drosophila rnelanogaster there are two glutamine synthetase (GS) (EC 6.3.1.2) isozymes. They are called GSI and GSII. The two enzymes have different subunits and different genetic determination. A DNA fragment that comprises 80% of the coding region of the glutamine synthetase gene of Chinese hamster ovary (CHO) cells allowed the identification and cloning of an homologous DNA fragment of Drosophila. This sequence is located at the 10B8-11 region on the X chromosome. Dose variation of a chromosomal segment from 9F3 to 10C1-2, which encompasses the 10B region, leads to proportional variations of GSII without apparently influencing the amount of GSI.


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