✦ LIBER ✦

Genetic determinants of basal cell carcinoma risk

✍ Scribed by Epstein, Ervin

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 82 KB
Volume: 36
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.1129

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Basal cell carcinomas are can be induced by ionizing radiation, in particular in patients with the rare autosomal dominant basal cell nevus syndrome (BCNS). These patients also are prone to medulloblastomas, and curative ionizing radiation therapy for the latter is followed soon by the development of sheets of basal cell carcinomas in the overlying skin. Positional cloning of the gene mutant is BCNS patients has identified the hedgehog signaling pathway as crucial to the development of all basal cell carcinomas and presumably to this susceptibility to post‐ionizing radiation carcinogenesis. Thus this pathway is a candidate for susceptibility to second, post‐therapy cancers in the broader population. Med. Pediatr. Oncol. 36:555–558, 2001. © 2001 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Genetic factors determining cutaneous ba

Genetic factors determining cutaneous basal cell carcinoma phenotype

✍ Ramachandran, Sudarshan ;Fryer, Anthony A. ;Strange, Richard C. 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB

## Abstract ## Background Basal cell carcinoma (BCC) patients demonstrate considerable phenotypic diversity. The basis of this heterogeneity is poorly understood. We have shown that presentational phenotypes are associated with BCC numbers. Thus, patients with a cluster of new BCC at any presentat

Giant basal cell carcinoma (T3): Who is

Giant basal cell carcinoma (T3): Who is at risk?

✍ Henry W. Randle; Randall K. Roenigk; David G. Brodland 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 735 KB

## Background: Giant basal cell carcinomas can cause extensive local invasion and disfigurement. this study determines in whom giant basal cell carcinomas develop. ## Methods: Fifty patients with giant basal cell carcinomas (over 5 cm, t3) were compared with other groups of patients with small (<

Risk of developing another basal cell ca

Risk of developing another basal cell carcinoma. A 5-year prospective study

✍ June K. Robinson 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB 👁 2 views

Basal cell carcinoma of the vulva

✍ Piura, Benjamin; Rabinovich, Alex; Dgani, Ram 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 56 KB 👁 2 views

Background and Objectives: Vulvar basal cell carcinoma (BCC) accounts for 7% of all vulvar cancers at two hospitals in the south of Israel. The purpose of this study was to investigate the clinical findings, treatment and outcome of patients with vulvar BCC treated at these institutions. Methods: Da

Basal cell carcinoma of the scrotum

✍ José I Esquivias Gómez; Antonio González-López; Encarnación Velasco; Tomás Pozo; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 160 KB

An 80‐year‐old man with a 7 year history of a slowly enlarging, asymptomatic scrotal nodule is presented. He had a negative history for sexually transmitted disease, trauma to the area, radiotherapy and chemical or arsenic exposure. The lesion was excised with a margin of 0.8 cm of normal skin. Exam

Rare Presentations of Basal Cell Carcino

Rare Presentations of Basal Cell Carcinoma

✍ Keyvan Nouri; Paolo Romanelli; Jennifer T. Trent; Roya Javid; Gloria Jimenez 📂 Article 📅 2002 🏛 Springer-Verlag 🌐 English ⚖ 61 KB