Genetic damage detected in CD-1 mouse pups exposed perinatally to 3′-azido-3′-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage

Genetic damage detected in CD-1 mouse pu

Genetic damage detected in CD-1 mouse pups exposed perinatally to 3′-azido-3′-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment

✍ Kristine L. Witt; Raymond R. Tice; Gary W. Wolfe; Jack B. Bishop 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB 👁 2 views

## Abstract We previously reported extraordinary increases in micronucleated erythrocytes in CD‐1 mouse pups exposed to 3′‐azido‐3′‐deoxythymidine (AZT) and dideoxyinosine (ddI; 50/250, 75/375, 150/750 mg/kg/day AZT/ddI) by gavage throughout gestation and lactation, followed by direct pup dosing be