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Genetic correction of X-linked chronic granulomatous disease with novel foamy virus vectors

✍ Scribed by Ilenia Chatziandreou; Elena Konstantina Siapati; George Vassilopoulos

Book ID
113616740
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
952 KB
Volume
39
Category
Article
ISSN
0301-472X

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πŸ“œ SIMILAR VOLUMES

Characterization of 11 novel mutations i
Characterization of 11 novel mutations in the X-linked chronic granulomatous disease (CYBB gene)
✍ BΓ©nΓ©dicte GΓ©rard; Jamel El Benna; FranΓ§oise Alcain; Marie-Anne Gougerot-Pocidalo πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 19 KB

The most frequent form of chronic granulomatous disease (CGD) is caused by inactivation of the CYBB gene, which encodes the gp91-phox subunit of phagocyte NADPH oxidase. This defect prevents phagocytes from producing reactive oxygen species and thus from eradicating bacterial and fungal infections.