Parkinson's disease is associated with mutations in the glucocerebrosidase gene, which result in the enzyme deficiency causing Gaucher disease, the most common lysosomal storage disorder. We have performed an exhaustive literature search and found that additional lysosomal storage disorders might be
✦ LIBER ✦
Genetic Convergence of Parkinson’s Disease and Lysosomal Storage Disorders
✍ Scribed by Deng, Hao; Xiu, Xiaofei; Jankovic, Joseph
- Book ID
- 127122494
- Publisher
- Springer
- Year
- 2014
- Tongue
- English
- Weight
- 534 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0893-7648
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## Abstract ## Background: Parkinson's disease (PD) is a common neurodegenerative disorder of unknown etiology. The characteristic α‐synuclein aggregation of PD is also a feature of Sanfilippo syndrome, a storage disorder caused by α‐__N__‐acetylglucosaminidase (__NAGLU__) gene mutations. We explo
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