✦ LIBER ✦

Genetic control of the expression of allelic Ig genes at the VHa locus in a1/a2 heterozygous rabbits

✍ Scribed by Alice Gilman-Sachs; Sheldon Dray; Katherine L. Knight

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 535 KB
Volume: 11
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830111210

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Heterozygous rabbits representing 9 of 15 possible a^1^ and a^2^ heavy chain haplotype gene combinations among rabbits in the University of Illinois colony were analyzed for ratios of al to a2 in serum immunoglobulin (Ig). The Ig from rabbits of the a^1^x^−^y^−^n^81^f^73^g^74^de^12,15^ heavy chain haplotype in combination with any of three a^2^‐associated heavy chain haplotypes have higher ratios of a1 to a2 than Ig from rabbits in which a^1^ is encoded by 4 other heavy chain haplotypes. For example, the mean a1: a2 ratio for adult a^1^x^−^y^−^n^81^f^73^g^74^de^12,15^/a^2^x^32^y^33,−^ n^82^,f^71^g^75^de^12,15^ rabbits was 12:1 compared to 5:1 for a^1^x^−^y^33,30^n^83^,f^71^g^75^de^12,15^/a^2^x^32^y^33,−^ n^82^,f^71^g^75^de^12,15^ heterozygous rabbits. Family studies indicated that the a1:a2 ratio was under the control of the heavy chain chromosomal region or a locus closely linked to it. Whether the regulation is due to varying numbers of V~H~ genes and/or J gene segments, a separate regulator gene, or more efficient joining of certain gene segments, has yet to be determined.

📜 SIMILAR VOLUMES

A lethal allele at the putative regulato

A lethal allele at the putative regulatory locus, cpc-1, of cross-pathway control in Neurospora crassa

✍ Barthelmess, Ilse B. 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 498 KB

The fusion allele of theFUT2(secretor ty

The fusion allele of theFUT2(secretor type α(1,2)-fucosyltransferase) gene at a high frequency and a newse385allele in a Korean population

✍ Kyoung Un Park; Junghan Song; Kyou Sup Han; Jin Q. Kim 📂 Article 📅 2005 🏛 Springer 🌐 English ⚖ 99 KB

Lack of allelic loss at the multiple end

Lack of allelic loss at the multiple endocrine neoplasia type 1(MEN-1) gene locus in a pancreatic ductal (non-endocrine) adenocarcinoma of a patient with the MEN-1 syndrome

✍ Cesare Bordi; Cinzia Azzoni; Tiziana D'Adda; Anacleto Peracchia; Alberto Falchet 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 951 KB

The gene responsible for multiple endocrine neoplasia type I (MEN-l) syndrome has been mapped to chromosome l lq13. It appears to function as a tumoursuppressor gene analogous to that for retinoblastoma and allelic losses involving the wild-type of the MEN-1 allele have been found in parathyroid and

Evidence for a new allele at the SERCA1

Evidence for a new allele at the SERCA1 locus affecting pork meat quality in part through the imbalance of Ca2+homeostasis

✍ J. Chai; Q. Xiong; P. P. Zhang; Y. Y. Shang; R. Zheng; J. Peng; S. W. Jiang 📂 Article 📅 2009 🏛 Springer 🌐 English ⚖ 265 KB

Association and linkage studies of the T

Association and linkage studies of the TAQI A1 allele at the dopamine D2 receptor gene in samples of female and male alcoholics

✍ Neiswanger, Katherine ;Hill, Shirley Y. ;Kaplan, Barry B. 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 698 KB

To address the controversy surrounding DRDS and alcoholism, we performed linkage and association studies utilizing alcoholic men from high-density families largely uncontaminated by other psychopathology and female alcoholics for whom secondary drug dependence (averaging 10 years later onset) was a

Co-segregation of alleles at a microsate

Co-segregation of alleles at a microsatellite locus within the macrophage expressed lysozyme gene and levels of serum lysozyme activity in two half-sib families of Polish Black and White Lowland cattle

✍ C. S. Pareek; K. Walawski; U. Czarnik; H-M Seyfert; V. Guiard; S. Grupe; M. Schw 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 290 KB

Alleles at a microsatellite locus within the macrophage expressed lysozyme gene were shown to co-segregate with lysozyme activity in two half-sib families of Polish Black and White Lowland cattle. The bimodal distribution of lysozyme activities in both progeny groups is concordant with the occurrenc