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Genetic control of the antibody response to allotypes of murine C4

✍ Scribed by Dominic G. Spinella; Laurie A. Roper; Howard C. Passmore

Publisher
Springer-Verlag
Year
1984
Tongue
English
Weight
318 KB
Volume
19
Category
Article
ISSN
0093-7711

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✦ Synopsis

The murine C4d allotypes are antigenic variants of the fourth component of the mouse complement system which are controlled by alternative alleles at the S region of the H-2 complex. The first of these to be defined was H-2.7, originally described by Hoecker and co-workers (1959) who detected the specificity on A.SW (H-2 ~) erythrocytes using an antiserum derived from immunization of strain A (H-Y) mice with lymphoid cells from A.CA (H-if) donors. This allotype was detected on erythrocytes of strains carrying the H-2 haplotypes f, j, p, and s by PVP

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