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Genetic control of T helper subset differentiation in Leishmania major infection of mice

โœ Scribed by Amy M Beebe; Daniel J Cua; Robert L Coffman

Book ID
108489103
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
138 KB
Volume
1
Category
Article
ISSN
1286-4579

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Leishmania major infection of inbred mic
Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases
โœ Deborah J. Fowell; Richard M. Locksley ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 275 KB

Leishmania major infection of inbred mice leads to a major dichotomous responsedeath or survival-that depends on the strain of mice. This finding has motivated efforts to locate genetic determinants of disease susceptibility. Genotyping studies have confirmed a complex multilocus trait, but studies