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Genetic conflict and evolution of mammalian X-chromosome inactivation

✍ Scribed by Moore, Tom ;Hurst, Laurence D. ;Reik, Wolf

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
678 KB
Volume
17
Category
Article
ISSN
0192-253X

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✦ Synopsis

The existence of parentally imprinted gene expression in the somatic tissues of mammals and plants can be explained by a theory of intragenomic genetic conflict, which is a logical extension of classical parent-offspring conflict theory. This theory unites conceptually the phenomena of autosomal imprinting and X-chromosome inactivation. We argue that recent experimental studies of X-chromosome inactivation and androgenetic development address previously published predictions of the conflict theory, and we discuss possible explanations for the occurrence of random X-inactivation in the somatic tissues of eutherians. o 1995 WiIey-Liss, Inc.

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