Genetic code and optimal resistance to the effects of mutations
β Scribed by A. Figureau; M. Pouzet
- Publisher
- Springer Netherlands
- Year
- 1984
- Tongue
- English
- Weight
- 569 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1573-0875
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The emergence of genotypic resistance in protease and reverse transcriptase (RT) gene regions was longitudinally evaluated in plasma samples from a group of 12 HIV-1-infected patients treated with different combination of antiretroviral therapies and selected on the basis of their clinical failure.
This study evaluated the influence of zidovudine (ZDV) resistance mutations on the antiviral effect of the combination of stavudine (D4T) plus didanosine (ddI) in patients treated previously with ZDV plus zalcitabine (ddC). Twenty patients who had been treated with ZDV plus ddC for a median duration