Genetic characterization of G3 rotaviruses detected in Italian children in the years 1993–2005
✍ Scribed by Simona De Grazia; Vito Martella; Claudia Colomba; Antonio Cascio; Serenella Arista; Giovanni M. Giammanco
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 211 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
Abstract
In recent years an apparent increase in the frequency of detection of G3P[8] rotaviruses has been observed worldwide. Similarly, in Italy G3P[8] strains have been detected sporadically and in a scattered fashion over 20 years, whereas in 2003 and 2005 G3P[8] rotavirus activity increased markedly. By analysis of the VP7, VP4, VP6, and NSP4 genes of a selection of G3P[8] rotaviruses detected between 1993 and 2005, a remarkable sequence conservation was observed in the VP7, VP4, and VP6 genes. By converse, after 2002 the Italian G3P[8] strains were found to possess unique mutations in significant regions of the NSP4 protein. J. Med. Virol. 81:2089–2095, 2009. © 2009 Wiley‐Liss, Inc.