𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Genetic changes in breast cancer detected by comparative genomic hybridisation

✍ Scribed by Ruth L. Loveday; John Greenman; Deborah L. Simcox; Valerie Speirs; Philip J. Drew; John R.T. Monson; Michael J. Kerin

Publisher
John Wiley and Sons
Year
2000
Tongue
French
Weight
244 KB
Volume
86
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Breast cancer is characterised by a number of genetic aberrations. Our purpose was to use comparative genomic hybridisation (CGH) to screen breast carcinomas for copy number changes: 44 ductal and 8 lobular carcinomas were studied and a large number of genetic aberrations identified. Many of these showed similarity to previous CGH results, however, a number of loci not previously shown to have undergone frequent change were identified. This included copy number gains affecting chromosomes 1p, 4q, 5q, 6q and 13q. Furthermore, we have identified 2 regions of copy number change, the gain on 5p and deletion of 16q, which correlated with lobular carcinomas. Our results highlight several areas of the genome that may be important in the molecular genetics of breast cancer.

πŸ“œ SIMILAR VOLUMES

Genetic changes in familial prostate can
Genetic changes in familial prostate cancer by comparative genomic hybridization
✍ Annika RΓΆkman; Pasi A. Koivisto; Mika P. Matikainen; Tuula KuukasjΓ€rvi; Marita P πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 142 KB πŸ‘ 1 views

## Background: Germline mutations in recessive cancer predisposition genes are uncovered by somatic genetic deletions during tumor development. analysis of genetic changes in tumor tissues from patients with an inherited predisposition may therefore highlight regions of the genome containing suscep

Genetic alterations in lobular breast ca
Genetic alterations in lobular breast cancer by comparative genomic hybridization
✍ Takafumi Nishizaki; Karen Chew; Lisa Chu; Jorma Isola; Anne Kallioniemi; Noel We πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 French βš– 71 KB πŸ‘ 1 views

Infiltrating lobular carcinoma (ILC) and infiltrating ductal carcinoma (IDC) are distinguished by their histopathological appearance. However, little is known about the differences in genetic changes between lobular cancers and ductal cancers. We used comparative genomic hybridization (CGH) and comp

Detection of recurrent chromosomal gains
Detection of recurrent chromosomal gains and losses in primary nasopharyngeal carcinoma by comparative genomic hybridisation
✍ Angela Bik-Yu Hui; Kwok-Wai Lo; Sing-Fai Leung; Peter Teo; Michael K.F. Fung; K. πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 374 KB πŸ‘ 1 views

## Nasopharyngeal carcinoma (NPC) is a common cancer in Southern China but rare in Western countries. To search for genetic alterations in NPC, we examined a series of 20 primary tumours with comparative genomic hybridisation. The identified common chromosomal alterations included gain of chromoso

Genetic alterations in primary breast ca
Genetic alterations in primary breast cancers and their metastases: Direct comparison using modified comparative genomic hybridization
✍ Takafumi Nishizaki; Sandy DeVries; Karen Chew; William H. Goodson III; Britt-Mar πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 103 KB πŸ‘ 1 views

Breast tumor development and progression are thought to be driven by an accumulation of genetic alterations, but little is known about the specific changes that occur during the metastatic process. We analyzed pairs of primary breast cancers and their matched lymph node metastases from 11 patients,