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Genetic basis of tissue specificity of vasculitis in MRL/lpr mice

✍ Scribed by Akihiro Yamada; Tatsuhiko Miyazaki; Ling-Min Lu; Masao Ono; Mitsuko R. Ito; Miho Terada; Shiro Mori; Kazuya Hata; Yoshimi Nozaki; Shuichi Nakatsuru; Yusuke Nakamura; Morikazu Onji; Masato Nose

Book ID
101645357
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
253 KB
Volume
48
Category
Article
ISSN
0004-3591

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✍ Wei-Min Qu; Tatsuhiko Miyazaki; Miho Terada; Ling-Min Lu; Miyuki Nishihara; Akih πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 185 KB πŸ‘ 1 views

An MRL/MpJ strain of mice bearing the Fas deletion mutant gene, lpr (MRL/lpr), composed of genomes derived from LG/J, AKR/J, C3H/Di and C57BL/6J mice, develops systemic vasculitis coincidentally with other collagen diseases, but a C3H/HeJ-lpr/lpr (C3H/lpr) strain does not. In a genome-wide screening