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Genetic basis of antibiotic resistance in pathogenic Acinetobacter species

✍ Scribed by Laurent Poirel; Rémy A. Bonnin; Patrice Nordmann

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
98 KB
Volume
63
Category
Article
ISSN
1521-6543

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✦ Synopsis

Abstract

Antibiotic resistance in Acinetobacter spp., particularly Acinetobacter baumannii, is increasing rapidly. A. baumannii possesses two intrinsic β‐lactamase genes, in addition to weak permeability and efflux systems, that together confer a natural reduced susceptibility to antibiotics. In addition, numerous acquired mechanisms of resistance have been identified in A. baumannii. The very high genetic plasticity of A. baumannii allows an accumulation of resistance determinants that give rise to multidrug resistance at an alarming rate. The role of novel genetic elements, such as resistance islands, in concentrating antibiotic resistance genes in A. baumannii requires detailed investigation in the near future. © 2011 IUBMB IUBMB Life, 63(12): 1061–1067, 2011

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