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Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease

✍ Scribed by Aleksandar Rakovic; Barbara Stiller; Ana Djarmati; Antonia Flaquer; Jan Freudenberg; Mohammad-Reza Toliat; Michael Linnebank; Vladimir Kostic; Katja Lohmann; Sebastian Paus; Peter Nürnberg; Christian Kubisch; Christine Klein; Ullrich Wüllner; Alfredo Ramirez

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
905 KB
Volume
24
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

A role of ATP13A2 in early‐onset Parkinsonism (EOP) has been proposed. Conversely, the contribution of this ATPase to late‐onset Parkinson's disease (PD) remains unexplored. We therefore conducted a case–control association study in this age‐of‐onset group with PD. The initial sample was of German origin and consisted of 220 patients with late‐onset PD (mean age of onset 60.1 years) and 232 age‐matched unrelated controls. Five single nucleotide polymorphisms (SNPs) covering ATP13A2 and its common haplotypes were genotyped. The overall association results in this sample were negative. Interestingly, gender stratification gave a positive result for SNP rs11203280 (P~UNC~ = 0.016) in men. This result could not be reproduced in a replication sample of German and Serbian origin composed of 161 patients with late‐onset PD (mean age of onset 51.7 years) and 150 age‐ and ethnic‐matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late‐onset PD. © 2008 Movement Disorder Society

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