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Genetic association of the humoral and cellular immune responses of rats to moloney sarcomas

✍ Scribed by Bruce C. Veit; Joe M. Jones; Glenn A. Miller; Joseph D. Feldman

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
776 KB
Volume
19
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Brown Norway (BN), Lewis (Le), F^1^ hybrids of Le × BN (LBN) and parent‐to‐LBN backcross rats were tested for cellular and humoral responses to a BN Moloney sarcoma. Regardless of AgB phenotype, BN backcrosses produced low levels of cell‐mediated cytotoxicity (CMC) that were comparable to those of BN parents. Le backcrosses developed high levels of CMC similar to those produced in Le parents. An inverse relationship between levels of CMC and serum antibodies (cytotoxic for tumor cells and anti‐p30 of MuLV) was observed; BN parents and backcrosses produced high levels of serum antibodies whereas levels in Le parents and backcrosses were low. LBN hybrids developed relatively high levels of CMC and serum antibodies. An additional finding was that the CMC response in Le parents and back‐crosses was directed primarily against tumor‐associated antigens rather than histocompatibility antigens expressed on the tumor cells. The results suggest that humoral and cellular responses to Moloney sarcoma in rats are not determined solely by the major AgB histocompatibility locus but do have a genetic association. This genetic association was detected with a ^51^Cr release assay which detects T‐cells, suggesting that select populations of effector T‐cells may be genetically regulated.

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