𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Genetic association of Huntington's disease and restless legs syndrome? A family report

✍ Scribed by Stefan Evers; Florian Stögbauer

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
52 KB
Volume
18
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We report on a family with comorbidity of Huntington's disease (HD) and idiopathic restless legs syndrome (RLS). All family members investigated and affected by RLS are also affected by HD, but not vice versa. The association of HD and RLS is discussed with respect to dopaminergic dysfunction. © 2002 Movement Disorder Society

📜 SIMILAR VOLUMES

Childhood-onset restless legs syndrome:
Childhood-onset restless legs syndrome: Clinical and genetic features of 22 families
✍ Hiltrud Muhle; Anja Neumann; Katja Lohmann-Hedrich; Thora Lohnau; Yang Lu; Susen 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 101 KB

## Abstract Restless legs syndrome (RLS) is a sensory‐motor disorder that is underdiagnosed in children and often misclassified as attention deficit hyperactivity disorder. Five different gene loci (__RLS1‐5__) and three susceptibility loci have been identified in adult‐onset RLS. We included 23 ch

Prevalence and clinical profile of restl
Prevalence and clinical profile of restless legs syndrome in Parkinson's disease
✍ Dagmar Verbaan; Stephanie M. van Rooden; Jacobus J. van Hilten; Roselyne M. Rijs 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 75 KB

## Abstract Parkinson's disease (PD) and restless legs syndrome (RLS) have a dopaminergic link. More insight in the clinical profile of RLS in patients with PD may benefit our understanding of this link. The aims of this study were to evaluate the frequency and clinical profile of RLS in a large co

Family-based association study of the re
Family-based association study of the restless legs syndrome loci 2 and 3 in a European population
✍ David Kemlink; Olli Polo; Pasquale Montagna; Federica Provini; Karin Stiasny-Kol 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB 👁 1 views

## Abstract Three loci for the restless legs syndrome (RLS) on chromosomes 12q, 14q, and 9p (RLS1, RLS2, and RLS3) have been mapped, but no gene has been identified as yet. RLS1 has been confirmed in families from three different populations. We conducted a family‐based association study of 159 Eur

Restless legs syndrome is a common featu
Restless legs syndrome is a common feature of adult celiac disease
✍ Marcello Moccia; Maria Teresa Pellecchia; Roberto Erro; Fabiana Zingone; Sara Ma 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 86 KB

Restless legs syndrome (RLS) is a common neurological condition, frequently idiopathic, sometimes associated with specific disorders such as iron deficiency. We investigated RLS prevalence in celiac disease (CD), an autoimmune disease characterized by several features such as malabsorption-related i

Family-based and population-based associ
Family-based and population-based association studies validate PTPRD as a risk factor for restless legs syndrome
✍ Qinbo Yang; Lin Li; Rong Yang; Gong-Qing Shen; Qiuyun Chen; Nancy Foldvary-Schae 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 103 KB 👁 1 views

## Abstract ## Objective: We previously mapped a genetic locus for restless legs syndrome (RLS) to chromosome 9p22‐24 (__RLS3__) and a later genome‐wide association study (GWAS) implicated the __PTPRD__ gene at the __RLS3 l__ocus as a susceptibility gene for RLS. However, from the standpoint of ge