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Genetic and functional analysis of commonMRC1exon 7 polymorphisms in leprosy susceptibility

✍ Scribed by Andrea Alter; Louis de Léséleuc; Nguyen Van Thuc; Vu Hong Thai; Nguyen Thu Huong; Nguyen Ngoc Ba; Cynthia Chester Cardoso; Audrey Virginia Grant; Laurent Abel; Milton Ozório Moraes; Alexandre Alcaïs; Erwin Schurr


Book ID
106134942
Publisher
Springer
Year
2009
Tongue
English
Weight
414 KB
Volume
127
Category
Article
ISSN
0340-6717

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Several sequence changes have been reported in hereditary angioedema patients in intron 2 of the SERPING1/C1NH gene, but their consequences on splicing have not been determined. We examined in cell transfection assays the consequences at the mRNA level of splicing mutations affecting either the +3 o