Genetic and ethanol-related differences in maternal behavior and offspring viability in mice

✍ Scribed by Dr. Karen M. Swanberg; James R. Wilson

• Book ID: 102145365
• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 395 KB
• Volume: 12
• Category: Article
• ISSN: 0012-1630
• DOI: 10.1002/dev.420120107

✦ Synopsis

Abstract

Primiparous female mice of 2 lines genetically selected for different narcotic responses to ethanol were administered 10% (v/v) ethanol in their drinking water during Days 2–14 of lactation. Ethanol treatment resulted in a marked decrease in growth and viability of pups in both lines. Fewer offspring of the ethanol‐sensitive line survived to weaning, apparently because of the failure of a large number of dams to exhibit maternal care. The combination of ethanol treatment and an additional environmental stressor (mouse hepatic virus) had a devastating effect on maternal behavior and offspring survival in the ethanol‐sensitive line, but far less effect on the ethanol‐insensitive mice. Thus, ethanol‐sensitive animals appear to be more susceptible to a variety of stressors, including ethanol.