Genetic and Epigenetic Modification of MLH1
β Scribed by Manuel Perucho; Shannon A. Kuismanen; Mari T. Holmberg; Reijo Salovaara
- Book ID
- 117022294
- Publisher
- American Society for Investigative Pathology
- Year
- 2000
- Tongue
- English
- Weight
- 53 KB
- Volume
- 157
- Category
- Article
- ISSN
- 0002-9440
No coin nor oath required. For personal study only.
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## Abstract Epigenetic silencing of __MLH1__ is the most common cause of defective DNA mismatch repair in endometrial and colorectal cancers. We hypothesized that variation in the __MLH1__ gene might contribute to the risk for __MLH1__ methylation and epigenetic silencing. We undertook a caseβcontr