Genetic and epigenetic factors that influence the occurrence of spontaneous lymphoid tumors in crosses of mice of high- and low-incidence strains
✍ Scribed by Maria L. Duran-Reynals; Anna S. Kadish; Frank Lilly
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- French
- Weight
- 558 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
AKR mice, which spontaneously develop >90% incidence of lymphocytic leukemia (LL), crossed with SJL mice, which show >80% incidence of Hodgkin'slike reticulum-cell sarcoma (RCS), produced FI progeny showing incidences of 30% LL and 0% RCS. Thus, each strain possesses one or more dominant genes capable of interfering with the emergence of the tumor type typical of the other strain. Although mice of reciprocal FI crosses showed a profound difference in expression of endogenous ecotropic murine leukemia virus (E-MuLV) due to a maternal resistance factor transmitted by SJL females but not males, the two populations did not differ detectably in LL incidence. Like AKR mice, mice of 5 other strains studied (C58, DBN2, PL, RF and STlb) possessed one or more genes conferring resistance t o RCS in F, crosses with SJL. Analysis of LL incidences in FI generations of all possible crosses among these 7 strains revealed 4 different categories of strains with respect to susceptibilityhesistance to LL; only ST/b mice, which show no significant incidence of spontaneous LL, lacked genes that could suppress the disease in crosses with high-or moderate-incidence strains. SJL mice treated topically with 3-methylcholanthrene (MCA) developed a 50% incidence of LL, mostly before one year of age; treated mice surviving after one year of age developed a high incidence of RCS. 3T0 whom reprint requests should be sent.