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Genetic and epigenetic contribution to complex traits

✍ Scribed by Kilpinen, H.; Dermitzakis, E. T.

Book ID: 115476712
Publisher: Oxford University Press
Year: 2012
Tongue: English
Weight: 88 KB
Volume: 21
Category: Article
ISSN: 0964-6906
DOI: 10.1093/hmg/dds383

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## Abstract The ends of human chromosomes are protected from the degradation associated with cell division by 15–20 kb long segments of hexameric repeats of 5′‐TTAGGG‐3′ termed telomeres. In normal cells telomeres lose up to 300 bp of DNA per cell division that ultimately leads to senescence; howev