Genetic and epigenetic classifications define clinical phenotypes and determine patient outcomes in colorectal cancer

Insulin-like growth factor 1 expression

Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan

✍ Mario Scartozzi; Alessandra Mandolesi; Riccardo Giampieri; Chiara Pierantoni; Fo 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 245 KB

## Abstract Seventy to 40% of K‐RAS wild type colorectal tumors does not seem to benefit from treatment with antiepidermal growth factor receptor (anti‐EGFR) monoclonal antibodies. Recent data suggested that in presence of IGF‐1 system, altered activation colorectal cancer cells may escape anti‐EGF