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Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomas

✍ Scribed by Ken-ichi Kawaguchi; Yoshinao Oda; Tsuyoshi Saito; Tomonari Takahira; Hidetaka Yamamoto; Sadafumi Tamiya; Yukihide Iwamoto; Masazumi Tsuneyoshi

Book ID
116533900
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
212 KB
Volume
36
Category
Article
ISSN
1532-8392

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πŸ“œ SIMILAR VOLUMES

PTEN/MMAC1 gene mutation is a rare event
PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations
✍ Tsuyoshi Saito; Yoshinao Oda; Ken-ichi Kawaguchi; Tomonari Takahira; Hidetaka Ya πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 French βš– 111 KB

## Abstract The tumor suppressor gene PTEN/MMAC1 was identified on chromosome 10q23.3, which is homozygously deleted in many human malignancies. The loss of chromosome 10q was also frequently reported in some types of soft tissue sarcomas. Our study was designed to investigate the frequency of PTEN