𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Genetic and environmental components of serum creatine kinase (CK) and pyruvate kinase (PK) in normal twins: Implication for genetic risks estimates in Duchenne muscular dystrophy carriers

✍ Scribed by Rapaport, Debora ;Colletto, Gloria M. D. D. ;Zatz, Mayana ;Opitz, John M. ;Reynolds, James F.

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
430 KB
Volume
31
Category
Article
ISSN
0148-7299

No coin nor oath required. For personal study only.

✦ Synopsis

The serum activity of creatine kinase (CK) and pyruvate kinase (PK) was measured in 98 pairs of same-sex Brazilian twins. The purpose of this study was to estimate the genetic and environmental components of serum activity levels for both enzymes. Heritabilities were estimated separately by path analysis in each sex. The results showed that CK and PK activities are under genetic control in normal males and females. Environmental components were not statistically significant for CK or PK. The genetic component of both enzymes estimated in females has implications in the calculation of genetic risks for Duchenne muscular dystrophy carriers.

📜 SIMILAR VOLUMES

Pyruvate-kinase (PK) and creatine-kinase
Pyruvate-kinase (PK) and creatine-kinase (CK) in normal pregnancy and its implication in genetic counseling of duchenne muscular dystrophy (DMD)
✍ Zatz, Mayana ;Karp, L. E. ;Rogatko, A. ;Opitz, John M. 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 405 KB 👁 1 views

## Abstract The activities of pyruvate‐kinase (PK) and creatine‐kinase (CK) were measured in 50 normal pregnant women in both serum and amniotic fluid. Serum PK activity was found to be significantly higher in pregnant than in nonpregnant women, while serum CK did not differ significantly between t