Genetic and biochemical mechanisms limiting fipronil toxicity in the LPR strain of house fly, Musca domestica
✍ Scribed by Wen, Zhimou; Scott, Jeffrey G
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 145 KB
- Volume
- 55
- Category
- Article
- ISSN
- 1526-498X
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✦ Synopsis
Fipronil is a new insecticide which exerts its toxic action by interacting with the insect GABA-gated chloride channel. Previous studies have shown that cyclodiene-resistant insects have low to moderate levels of cross-resistance to ®pronil, while other resistant strains are usually susceptible. In contrast, we recently found a strain (LPR) of house ¯y (Musca domestica L) with 15-fold crossresistance to ®pronil that was not associated with cyclodiene resistance. Fipronil cross-resistance in LPR was inherited as an intermediately dominant, autosomal, multigenic trait. [ 14 C]Fipronil was observed to penetrate into LPR ¯ies more slowly than into susceptible ¯ies. S,S,S-tributylphosphorotrithioate and diethyl maleate pretreatment did not reduce the level of ®pronil cross-resistance, while piperonyl butoxide resulted in a slight decrease. These results indicate that decreased penetration and monooxygenase-mediated detoxi®cation may be mechanisms contributing to ®pronil cross-resistance in the LPR strain.