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Genetic and behavioral aspects of pharmacologically induced arousal

✍ Scribed by Gilbert W. Meier; Jimmy L. Hatfield; Donald P. Foshee


Publisher
Springer
Year
1963
Tongue
English
Weight
573 KB
Volume
4
Category
Article
ISSN
0033-3158

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The enzyme hypoxanthine phosphoribosyltransferase (HPRT), expressed at low levels in non-neuronal tissues and higher levels in the brain, catalyzes the cellular salvage of the purine bases hypoxanthine and guanine. A complete deficiency of HPRT results in Lesch-Nyhan syndrome (LNS). LNS is character