Genetic analysis ofad-3 mutants induced by AF-2 and two other nitrofurans in neurospora crassa
✍ Scribed by Ong, Tong-Man ;de Serres, F. J.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1981
- Weight
- 424 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0192-2521
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✦ Synopsis
Abstract
Our previous studies have shown that the nitrofurans AF‐2, SQ18506, and FANFT are potent mutagens in Neurospora crassa. The genetic damage produced by these chemicals at the ad‐3 region in N crassa has been characterized by a series of genetic tests. The results of these tests indicate that all three agents induce a high frequency of point mutations and probably a low frequency of multilocus deletions. A comparison of the complementation patterns among the AF‐2‐induced ad‐3B mutants and those induced by other chemical agents indicates that the spectra of intragenic alterations induced by AF‐2 in N crassa are similar to those induced by monofunctional alkylating agents.