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Genetic analysis of the molecular basis for β-adrenergic receptor subtype specificity

✍ Scribed by Richard A. F. Dixon; Wendy S. Hill; Mari R. Candelore; Elaine Rands; Ronald E. Diehl; Mark S. Marshall; Irving S. Sigal; Catherine D. Strader


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
771 KB
Volume
6
Category
Article
ISSN
0887-3585

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✍ Roberta Siegwart; Karin Krähenbühl; Sachar Lambert; Uwe Rudolph 📂 Article 📅 2003 🏛 BioMed Central 🌐 English ⚖ 623 KB

Background: Amino acids in the β subunit contribute to the action of general anaesthetics on GABA A receptors. We have now characterized the phenotypic effect of two β subunit mutations in the most abundant GABA A receptor subtype, α1β2γ2. ## Results: The β2(N265M) mutation in M2 decreased the mo