Genetic analysis of IDDM: The GAW5 multiplex family dataset

✍ Scribed by Dr. M. P. Baur; R. Fimmers; C. Fritsche; M. Hümmelink; M. Neugebauer; R. T. Acton; T. Hodge; J. Barbosa; J. Bertrams; K. Fehsel; H. Kolb; H. Rothe; B. Boehm; A. Cambon-Thomsen; P. Avoustin; H. Coppin; J. Darnaud; P. Massabie; E. Ohayon; C. de Preval; J. P. Tauber; M. Thomsen; E. Colle; M. J. MacDonald; D. Nevin; J. L. Gottschall; G. T. Nepom; D. M. Robinson; S. Holbeck; J. P. Palmer; J. Nerup; J. I. Rotter; C. Vadheim; C. Rittner; P. Schneider; M. J. Sheehy; N. J. Cox; L. Baker; R. S. Spielman

• Book ID: 102224648
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 317 KB
• Volume: 6
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/gepi.1370060105

✦ Synopsis

In a collaborative effort by 12 centers from Europe and North America, data were assembled from 94 multiplex families with insulin-dependent diabetes mellitus (IDDM) for analysis of genetic and other factors of possible etiological importance. The dataset contains information on the following genetic markers: HLA-DRP and -DQP restriction fragment length polymorphisms (RFLPs), three RFLPs detected with two probes that map 5' to the insulin gene, the serologically defined HLA loci, and the immunoglobulin allotypes. Data also were included for autoantibodies to insulin and pancreatic islet cells as possible indicators of pathogenesis and for antibodies to certain viruses that have been implicated as "triggering" agents in IDDM. Medical history of family members was obtained by means of a uniform questionnaire. Identical copies of the dataset were distributed to anyone