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Genetic analysis of human breast cancer: Literature review and description of family data in workshop

✍ Scribed by Mary-Claire King; Lisa A. Cannon; Joan E. Bailey-Wilson; F. J. Cleton; N. DeJong-Bakker; E. J. Gardner; O. Jacobsen; M-C. King; H. T. Lynch; M. H. Skolnick

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
616 KB
Volume
3
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

THE STUDY OF BREAST CANCER BY GENETIC ANALYSIS

Breast cancer is a very difficult disease to study using the it is sex-dependent, with late age at tools of genetic analysis: onset, and of complex etiology. However, breast cancer is undeniably important: it is the most common cause of cancer death among American and Western European women, causing more than 37,000 deaths annually (26 per 100,000 women per year) in the United States. Breast cancer is also the most common cancer (excluding skin) among women in the United States: 86 new cases per 100,000 women per year (Horm et al., 1984). Furthermore, familial aggregation is one of the most important risk factors for breast cancer, and there is considerable evidence that the disease may have a genetic component (reviewed in e.g. Anderson, 1982;

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