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Genetic analysis of hepatitis a virus outbreak in france confirms the co-circulation of subgenotypes Ia, Ib and reveals a new genetic lineage

✍ Scribed by Mauro Costa-Mattioli; Serge Monpoeho; Claire Schvoerer; Bernard Besse; Marie-Helene Aleman; Sylviane Billaudel; Juan Cristina; Virginie Ferré

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
173 KB
Volume
65
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Genetic analysis of selected genome regions of hepatitis A Virus (HAV) suggested that distinct genotype could be defined in different geographic locations. In order to study the degree of genetic variability among HAV isolated during a single epidemic outbreak, sequences from a 148 base pair segment within the VP1 amino terminal region were obtained for eight distinct HAV isolates from an outbreak that occurred in North Bretagne (France). These sequences were compared among themselves and with published sequences from 30 different strains that represented different HAV sub‐genotypes that were isolated all over the world. Phylogenetic analysis revealed an extensive genetic heterogeneity among strains belonging to the same outbreak and revealed co‐circulation of sub‐genotype IA, IB, and the presence of IIIA sub‐genotype for the first time in a Mediterranean country. J. Med. Virol. 65:233–240, 2001. © 2001 Wiley‐Liss, Inc.

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