Genetic Analysis of Complex Diseases, Second Edition

• Year: 2006
• Tongue: English
• Leaves: 494
• Category: Library

✦ Synopsis

Second Edition features the latest tools for uncovering the genetic basis of human disease

The Second Edition of this landmark publication brings together a team of leading experts in the field to thoroughly update the publication. Readers will discover the tremendous advances made in human genetics in the seven years that have elapsed since the First Edition. Once again, the editors have assembled a comprehensive introduction to the strategies, designs, and methods of analysis for the discovery of genes in common and genetically complex traits. The growing social, legal, and ethical issues surrounding the field are thoroughly examined as well.

Rather than focusing on technical details or particular methodologies, the editors take a broader approach that emphasizes concepts and experimental design. Readers familiar with the First Edition will find new and cutting-edge material incorporated into the text:

• Updated presentations of bioinformatics, multiple comparisons, sample size requirements, parametric linkage analysis, case-control and family-based approaches, and genomic screening
• New methods for analysis of gene-gene and gene-environment interactions
• A completely rewritten and updated chapter on determining genetic components of disease
• New chapters covering molecular genomic approaches such as microarray and SAGE analyses using single nucleotide polymorphism (SNP) and cDNA expression data, as well as quantitative trait loci (QTL) mapping

The editors, two of the world's leading genetic epidemiologists, have ensured that each chapter adheres to a consistent and high standard. Each one includes all-new discussion questions and practical examples. Chapter summaries highlight key points, and a list of references for each chapter opens the door to further investigation of specific topics.

Molecular biologists, human geneticists, genetic epidemiologists, and clinical and pharmaceutical researchers will find the Second Edition a helpful guide to understanding the genetic basis of human disease, with its new tools for detecting risk factors and discovering treatment strategies.Content:
Chapter 1 Basic Concepts in Genetics and Linkage Analysis (pages 1–49): Elizabeth C. Melvin and Marcy C. Speer
Chapter 2 Defining Disease Phenotypes (pages 51–89): Arthur S. Aylsworth
Chapter 3 Determining Genetic Component of a Disease (pages 91–115): Allison Ashley?Koch
Chapter 4 Patient and Family Participation in Genetic Research Studies (pages 117–151): Chantelle Wolpert, Amy Baryk Crunk and Susan Estabrooks Hahn
Chapter 5 Collection of Biological Samples for DNA Analysis (pages 153–166): Jeffery M. Vance
Chapter 6 Methods of Genotyping (pages 167–192): Jeffery M. Vance
Chapter 7 Data Analysis Issues in Expression Profiling (pages 193–217): Simon Lin and Michael Hauser
Chapter 8 Information Management (pages 219–235): Carol Haynes and Colette Blach
Chapter 9 Quantitative Trait Linkage Analysis (pages 237–253): Jason H. Moore
Chapter 10 Advanced Parametric Linkage Analysis (pages 255–281): Silke Schmidt
Chapter 11 Nonparametric Linkage Analysis (pages 283–328): Elizabeth R. Hauser, Jonathan Haines and David E. Goldgar
Chapter 12 Linkage Disequilibrium and Association Analysis (pages 329–353): Eden R. Martin
Chapter 13 Sample Size and Power (pages 355–396): Yi?Ju Li, Susan Shao and Marcy Speer
Chapter 14 Complex Genetic Interactions (pages 397–421): William K. Scott and Joellen M. Schildkraut
Chapter 15 Genomics and Bioinformatics (pages 423–454): Judith E. Stenger and Simon G. Gregory
Chapter 16 Designing a Study for Identifying Genes in Complex Traits (pages 455–468): Jonathan L. Haines and Margaret A. Pericak?Vance