In breast and colon adenocarcinomas methylation patterns at CCGG sites of several loci located on the short arm of chromosome 11 were determined by Southern blot analysis. Results obtained indicate that all tumor samples (20/20) exhibit DNA methylation changes when compared to their normal counterpa
โฆ LIBER โฆ
Genetic alterations on chromosome 17 in human breast cancer: relationships to clinical features and DNA ploidy
โ Scribed by Masahiro Watatani; Koichi Nagayama; Yukio Imanishi; Kazuyoshi Kurooka; Tomio Wada; Hiroki Inui; Kyoko Hirai; Masatoshi Ozaki; Masayuki Yasutomi
- Publisher
- Springer US
- Year
- 1993
- Tongue
- English
- Weight
- 917 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
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โ 801 KB
Primary breast tumors were tested for loss of heterozygosity (LOH), on chromosome 9p with microsatellite markers restricted to a 28 cM region including the MTSl gene. LOH was found with at least I marker in 38% of the 20 I cases analyzed. A high frequency of deletions was detected at the 9p23-pZI re