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Genetic alterations of the β-catenin gene lead to bone development disorders and diseases

✍ Scribed by Di Chen

Book ID
116323677
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
63 KB
Volume
47
Category
Article
ISSN
8756-3282

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␤-catenin has been identified as an oncogene. Phosphorylation of sites encoded by exon 3 of the ␤-catenin gene facilitates degradation of this protein by the adenomatous polyposis coli (apc) gene product. Mutations in these sites or inactivation of apc lead to stabilization of ␤-catenin, which then