Genetic alterations in prostate cancer
β Scribed by Jonathan L. Chin; Robert E. Reiter
- Book ID
- 107554837
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 609 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1527-2737
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## Abstract The genetic alterations that underlie prostate tumorigenesis are assumed to comprise gain or loss of specific chromosomal regions, whole chromosomes, or sequenceβspecific mutations. Existing data have not demonstrated clear specificity of whole chromosome or regional chromosomal gain or
The multistep nature of carcinogenesis has been repeatedly demonstrated for a variety of human cancers. Concomitant mutational activation of genes that promote cellular growth (i.e., oncogenes) and inactivation of genes that normally act to restrict or otherwise regulate growth (i.e., tumor suppress