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Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from Swiss (CD-1) male mice exposed transplacentally to AZT

✍ Scribed by Hue-Hua L. Hong; June Dunnick; Ronald Herbert; Theodora R. Devereux; Yongbaek Kim; Robert C. Sills

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 242 KB
Volume: 48
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.20197

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Hong H-HL, Dunnick J, Herbert R, Devereux TR, Kim Y, Sills RC (2007): Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from Swiss (CD-1) male mice exposed transplacentally to AZT. Environ Mol Mutagen 48:299–306.

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## Abstract A transplacental carcinogenicity study was conducted by exposing pregnant Swiss (CD‐1) mice to 0, 50, 100, 200, or 300 mg 3′‐azido‐3′‐deoxythymidine (AZT)/kg body weight (BW) daily for the duration of gestation (18–19 days) [National Toxicology Program,2006]. The incidence of alveolar/b