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Genetic alterations in juvenile nasopharyngeal angiofibromas

✍ Scribed by Cláudia M. Coutinho-Camillo; M. Mitzi Brentani; Maria A. Nagai

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
131 KB
Volume
30
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign neoplasm of the nasopharynx that accounts for 0.5% of all head and neck tumors. Although histologically benign in appearance, JNAs are locally aggressive and destructive, spreading from the nasal cavity to the nasopharynx, paranasal sinuses, and orbit skull base with intracranial extension. The gender selectivity of JNA and the relatively young age at diagnosis suggest hormone‐dependent development. Hormonal disorders have been reported in patients with JNA, and androgen and estrogen receptors have been identified in tumor tissue; however, a hormonal influence on JNA is controversial. Recent studies have attempted to further delineate the pathogenesis of JNA through analysis of genetic and molecular changes. Understanding of the molecular mechanisms involved in JNA might improve prevention, prognosis, and treatment of this tumor. In this review, we discuss published studies addressing the possible molecular pathways that might be involved in the development of JNA. © 2008 Wiley Periodicals, Inc. Head Neck, 2008

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Juvenile nasopharyngeal angiofibroma
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## Abstract ## Objectives: Juvenile nasopharyngeal angiofibroma (JNA) is a rare, benign tumor of the nasopharynx, exclusively affecting males in their teens and twenties. Historically, it has been thought that JNAs primarily receive their blood supply from the ipsilateral external carotid system.

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