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Genetic alterations in high grade astrocytoma related to prognosis

✍ Scribed by Sieger Leenstra; Theo J.M. Hulsebos

Book ID
119106329
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
90 KB
Volume
77
Category
Article
ISSN
0165-4608

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## Abstract ## BACKGROUND Two families of tumor suppressor genes, Cip/Kip (p21, p27, and 57) and INK4 (p15, p16, p18, and p19), regulate cell proliferation and neoplastic transformation. p27 exerts its suppressor effect through cyclin E‐dependent kinase (CDK2) by inhibiting the phosphorylation of