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Genetic alteration in the (Na+ + K+ ATPase transport system expressed in human lymphoblasts and their isolated plasma membranes

✍ Scribed by Julia E. Lever

Book ID: 102309256
Publisher: John Wiley and Sons
Year: 1976
Tongue: English
Weight: 355 KB
Volume: 89
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040890448

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✦ Synopsis

Abstract

A series of ouabain‐resistant human lymphoblastoid lines were shown to be genetically altered in the (Na^+^ + K^+^) ATPase transport system. The sensitivity to ouabain of Rb^+^ uptake in intact cells and (Na^+^ + K^+^)‐dependent ATP hydrolysis in purified plasma membrane vesicles was compared with measurement of ouabain binding to intact cells. Preliminary evidence for at least two categories of ouabain resistance was obtained.

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