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Genetic aberrations in oral or head and neck squamous cell carcinoma 3: clinico-pathological applications

✍ Scribed by C. Scully; J.K. Field; H. Tanzawa

Book ID: 114393656
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 160 KB
Volume: 36
Category: Article
ISSN: 1368-8375
DOI: 10.1016/s1368-8375(00)00023-3

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## Abstract We investigated the status of the PI 3‐kinase/AKT/PTEN signaling pathway in a series of 117 head and neck squamous cell carcinomas (HNSCC) in a search for molecular alterations in genes/proteins with potential prognostic value. For this purpose, __PIK3CA__ and __AKT2__ gene amplificatio