Genes that regulate interleukin-4 expression in T cells

✍ Scribed by Susanne J Szabo; Laurie H Glimcher; I-Cheng Ho

• Book ID: 104358791
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 664 KB
• Volume: 9
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(97)80177-x

✦ Synopsis

Interleukin

-4 is an immunomodulatory cytokine which plays a central role in the regulation of allergic and atopic immune responses. Significant progress has been made in gaining a detailed understanding of the transcriptional regulation of the interteukin-4 gene. The recent identification and characterization of several key transcription factors has helped to elucidate the molecular mechanisms of T helper cell cytokine gene expression.