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Genes modulated by histone acetylation as new effectors of butyrate activity

✍ Scribed by Fulvio Della Ragione; Vittoria Criniti; Valentina Della Pietra; Adriana Borriello; Adriana Oliva; Stefania Indaco; Tadashi Yamamoto; Vincenzo Zappia

Book ID: 117103089
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 295 KB
Volume: 499
Category: Article
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(01)02539-x

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## Abstract Butyric acid is well recognized as a histone deacetylase (HDAC) inhibitor, and changes in histone acetylation are thought to alter gene expression. The mechanism by which sodium butyrate (NaB) induces p21^WAF1/CIP1^, a critical gene involved in the antiproliferative effect of NaB, was s