Genes Induced in Programmed Cell Death of Neuronal PC12 Cells and Developing Sympathetic Neuronsin Vivo
β Scribed by Songli Wang; Angela J. Dibenedetto; Randall N. Pittman
- Book ID
- 115597820
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 720 KB
- Volume
- 188
- Category
- Article
- ISSN
- 0012-1606
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## Abstract Increasing evidence suggests that the regulation of neuronal cell death is complex. In this study we compared the neurotoxic effects of tumor necrosis factorβΞ± (TNFΞ±), nitric oxide, and thrombin on primary rat cortical cell cultures and the neuronal PC12 cell line. Release of lactate de
We used adenoviral-mediated gene transfer of human amyloid precursor proteins (h-APPs) to evaluate the role of various h-APPs in causing neuronal cell death. We were able to infect PC12 cells with very high efficiency because D90% of the cells were cytochemically positive for β€-galactosidase activit