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Gene(s) affecting the expression of Qa-1

โœ Scribed by Thomas H. Stanton; Sheila Carbon

Publisher
Springer-Verlag
Year
1982
Tongue
English
Weight
581 KB
Volume
16
Category
Article
ISSN
0093-7711

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โœฆ Synopsis

Lymphocytes from different strains vary in their expression of antigenic determinants encoded by the Qa1 locus. Thus, a lower percentage of cells from strains bearing H-2Dk are lysed in antibody-mediated cytotoxic tests. These cells fail to completely absorb anti-Qa1 activity from antisera. The unexpressed determinants are present in unactivated cells when subcellular fractions are tested and are detectable on the membrane of mitogen-activated lymphocytes. The gene(s) controlling this phenomenon are dominant and map to a region between H-2S and Tla.

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