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Generation of transgenic mice expressing human hemoglobin E

✍ Scribed by Qiuying Chen; Eric E. Bouhassira; Arnaud Besse; Sandra M. Suzuka; Mary E. Fabry; Ronald L. Nagel; Rhoda Elison Hirsch


Book ID
116303977
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
265 KB
Volume
33
Category
Article
ISSN
1079-9796

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Cl cotransport is involved in generating dense red blood cells (RBCs) in homozygotes for HbS (SS). We report on the properties of this transport system in RBCs from control and transgenic mice expressing high levels of human ␣ H and ␀ S chains. Unlike human SS RBCs, mouse RBCs incubated in isotonic